Understanding Cell Signaling through Systems Biology Approach: A Literature Review and Methodological Perspective
Autour(s)
- Chidi Yun, Miki Shun, Keypi Jackson, Ladson Newiduom, Ibrina Browndi
Abstract
Systems biology is an interdisciplinary field that integrates computational and experimental methods to analyze complex biological systems. The emergence of systems biology has led to a shift in the paradigm of understanding cell signaling, moving from a reductionist view of individual molecular interactions to a holistic approach of studying the system as a whole. In this article, we present a literature review of the application of systems biology to cell signaling and discuss the methodological perspective of studying molecular networks in cells. We highlight the importance of integrating multiple omics data sets to construct and analyze molecular networks and provide examples of network analysis methods. We also discuss the challenges and limitations of current systems biology approaches and suggest future directions in this field.