Systems Biology Approaches to Understanding Long-Term Potentiation (LTP) in Cell Signaling: Insights from Molecular Networks
European Journal of Scientific and Applied Sciences,
2023
Autour(s)
- John Balen, Lolade Nojeem, Wilmin Bitala, Utian Junta, Ibrina Browndi
Abstract
Long-term potentiation (LTP) is a fundamental mechanism of synaptic plasticity in the brain, which is essential for learning and memory. Understanding the regulatory mechanisms underlying LTP is crucial for the development of therapies for neurological disorders. Systems biology approaches, such as the construction of molecular networks and mathematical modeling, have been applied to study the regulatory mechanisms underlying LTP. This article provides an overview of the application of systems biology approaches to understanding LTP in cell signaling, with a focus on the insights gained from molecular networks.